Carmell’s BioActive Material: Advantages over Autologous PRP:
Note: When activated, platelets release PGF and adhesion molecules to mediate a variety of cellular interactions: chemotaxis, cell adhesion, migration, cell differentiation, and immunomodulatory activities. These platelet cell-cell interactions contribute to angiogenesis and inflammatory activities, ultimately to stimulate tissue repair processes. Carmell’s product utilizes platelet extracts following activation with calcium chloride.
Autologous Platelet Rich Plasma (PRP) has been widely used to treat a variety of orthopedic issues ranging from sports injuries to degenerative bone disorders.
The underlying scientific rationale for PRP therapy is that an injection of concentrated platelets at sites of injury may support and accelerate tissue repair via the release of many biologically active factors (growth factors, cytokines, lysosomes) and adhesion proteins that are responsible for initiating the hemostatic cascade, synthesis of new connective tissue, and revascularization.
Additionally, plasma proteins (e.g., fibrinogen, prothrombin, and fibronectin) are present in the platelet-poor plasma fraction (PPP). PRP concentrates can stimulate the supraphysiological release of growth factors to jump-start healing in chronic injuries and accelerate the acute injury repair process.
At all stages of the tissue repair process, a wide variety of growth factors, cytokines, and locally acting regulators contribute to most basic cell functions via endocrine, paracrine, autocrine, and intracrine mechanisms.
Source: Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci. 2020 Oct 21;21(20):7794. doi: 10.3390/ijms21207794. PMID: 33096812; PMCID: PMC7589810
In addition to the healing benefits provided by platelet and plasma-derived factors, Carmell’s orthopedic formulation includes beta tricalcium phosphate, a proven osteoconductive scaffolding material to support bone growth and regeneration.
Study design (HEAL I):